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2.
The appearance of unexpected peaks in capillary electrophoresis (CE) is common and can lengthen the time of method development as assay conditions and experimental parameters are varied to understand and mitigate the effects of the additional peaks. Additional peaks can arise when a single-analyte zone is split into multiple zones. Understanding the underlying mechanism of these phenomena, recognizing conditions that favor its presence, and knowing how to confirm and eliminate the effect are important for efficient method optimization. In this study, we examine how the overlap of analyte zones with the sample plug can lead to peak splitting. This is explored experimentally using dual detection CE, which enables both the sample plug and analyte zones to be independently and simultaneously measured from the same detection volume. Simulations performed via COMSOL Multiphysics confirm the origin of the splitting and help guide experiments to reduce and eliminate the effect. Our findings show that this peak splitting mechanism can arise in separations of both small and large molecules but is, especially, prevalent in separations of slowly migrating macromolecules. This effect is also more prevalent when using a short length-to-detector, as is commonly found in microfluidic applications. A simple diffusion-less model is introduced to develop strategies for reducing peak splitting that avoids modifying the apparatus, such as by lengthening the separation length, which can be difficult. Decreasing the sample plug length and slowing the electroosmotic flow can both reduce this effect, which is confirmed experimentally. 相似文献
3.
生物分子与纳米材料作用形成的“蛋白冠”影响纳米材料的物理和化学性质, 目前缺少有效的原位实时技术监测蛋白冠的形成过程. 本研究基于二氧化硅胶体晶体薄膜和反射干涉光谱法, 研究了三种代表性血液蛋白质在二氧化硅纳米粒子表面的蛋白冠形成过程, 结果表明这三种蛋白具有不同的蛋白冠形成过程及参数; 研究了人血清白蛋白在三种表面曲率的二氧化硅表面的蛋白冠形成过程, 结果表明曲率越大时, 蛋白冠形成速率越快, 厚度越大. 以血浆和全血样品为生物环境开展蛋白冠形成过程研究, 结果表明本研究的监测方法可以直接用于血浆和全血在纳米粒子表面蛋白冠的形成过程监测, 为纳米材料与生物分子的相互作用研究提供了一种简单可靠的评价技术. 相似文献
4.
We propose an inverse method, using a circular disk in diametrical compression, for the simultaneous determination of two
elastic constants,E andv, from a single displacement map. Moiré interferometry combined with the phase-shifting technique provides a full-field displacement
field. An overdeterministic approach using the least-squares method is implemented to fit the experimentally determined displacements
to the theoretical solution. An implementation guideline is provided, considering the effects of accidental rigid-body motions,
random noise and imperfect position of the origin. Accuracy and repeatability of the proposed method are verified experimentally. 相似文献
5.
本文基于光学和扫描显微平台,介绍了本研究组在微尺度实验力学检测技术和设备方面的最新研究成果。在检测技术方面涉及显微散斑干涉技术、微标记阵列检测技术、晶粒变形分析技术、光学探针动静态变形分析技术;在检测系统和装置方面介绍了新近开发的双视场薄膜检测系统、散斑微干涉系统、微标记检测平台、AFM和SEM单轴拉伸装置、三维微定位与加载系统、微力传感器及其标定装置、微动平台驱动装置等。探讨了微尺度实验力学检测中的问题和新的检测技术,给出了一些典型的应用和相关装置。 相似文献
6.
Troy N. Eichmann Timothy J. McIntyre Alexis I. Bishop Sosefo Vakata Halina Rubinsztein-Dunlop 《Shock Waves》2007,16(4-5):299-307
Flow visualization experiments were performed for supersonic and hypersonic nitrogen test gas flows over a cylinder. The results
were used to quantify the influence of three-dimensional effects on optical line-of-sight visualization measurements. Images
of cylindrical models of varying aspect ratios (length to diameter) were taken. Shock stand-off distance measurements for
the models were compared with a two-dimensional approximation and numerical simulations. For aspect ratios of two and above,
the two-dimensional approximation was acceptable within experimental uncertainty. The measured shock stand-off decreased by
less than 5% from an asymptotic value for an infinite length cylinder. For smaller aspect ratios, a correction factor for
the shock stand-off needs to be applied if comparisons between the two-dimensional approximation and experimental measurements
are to be drawn. An estimate of this correction factor has been derived from an empirical fit to the available data.
相似文献
7.
8.
Computational study of shock wave focusing in a log-spiral duct 总被引:1,自引:0,他引:1
The mechanism of shock wave focusing in a two-dimensional log-spiral duct has been investigated here numerically using a finite volume method. This approach is based on a MUSCL TVD scheme with flux-vector splitting applied to the Euler equations. The isopycnics determined from the calculations are compared with the experimental results obtained by use of holographic interferometric photography and are found to be in excellent qualitative agreement with the experiments. The computational results clarify the details of the wave interactions very near to the focus. In particular, phenomena such as the formation of secondary shock waves prior to the implosion, their interaction with the reflected shock and the formation of vortices after the implosion have been examined. 相似文献
9.
10.
The two refractive indices in the flow of a colloidal birefringent liquid are measured separately by means of a Mach-Zehnder
interferometer. For a quantitative evaluation of the resulting interferograms it is not necessary to linearize the respective
equations relating the refractive index distribution to the deformation velocity in the flow. Therefore it becomes possible
to perform velocity measurements in the non-Newtonian flow range. An additional measurement of the mean flow rate enables
one to determine the velocity field without the need of a calibration of the observed interference fringes. 相似文献